After failure of anti-PD-1 antibodies, retreatment with atezolizumab revealed limited efficacy in most retreated patients in NSCLC, however it was no correlation between efficacy of prior anti-PD-1 treatment and efficacy of retreatment with atezolizumab (Furuya et al., 2021). This evidence concerns the gene PDCD1 and non-small cell lung carcinoma.