The abundance of B cell and exhausted cell in lower-grade glioma was similar to that in GBM and was significantly higher in the high-HIF1A-expression group; meanwhile, the abundance of macrophage, monocyte, NK, natural regulatory T cell (nTreg), and type 1 regulator T cell (Tr1) was significantly higher in the low-HIF1A-expression group (all p < 0.05; Figures 2C,D). Here, HIF1A is linked to central nervous system cancer.