In addition, we found that the expression levels of T-cell exhaustion-related genes including CD40, GRB2, MKI67, NFATC3, PRDM1, TCF7, and TGFB1 were significantly higher, while those of CXCR5 and TOX were significantly lower after tumor recurrence (all p < 0.05; Figures 3B,C). Here, GRB2 is linked to neoplasm.