In GBM, the expression of T-cell exhaustion-related genes including PDL1 (CD274), B7H3 (CD276), FOXO1, and PRDM1 (all p < 0.05) in the high-HIF1A-expression group was higher than that in the low-HIF1A-expression group (Figures 1A,B). The gene discussed is CD276; the disease is glioblastoma.