Regarding other possible mechanisms for ameliorating NAFLD, recent findings suggest that BBR can reverse the HFD-induced suppression of fatty acid mitochondrial β-oxidation by activating sirtuin 3 (SIRT3)-mediated long-chain acyl-CoA dehydrogenase (LCAD) deacetylation, thereby improving systematic and hepatic lipid metabolism in mice (Xu et al., 2019). Here, SIRT3 is linked to metabolic dysfunction-associated steatotic liver disease.