miR-148a is down-regulated in the colon tissues of UC and CRC patients, and reduces the activation of NF-κB and STAT3 in macrophages of colon tissues by directly targeting upstream regulators of NF-κB and STAT3 pathway (including GP130, IKKα, IKKβ, IL1R1 and TNFR2). This evidence concerns the gene STAT3 and colorectal carcinoma.