High MMP-2 and -9 levels were associated with esophageal carcinomas (Koyama et al., 1990) and breast (Alrehaili et al., 2020), oral (Lin et al., 2004), bladder (Fouad et al., 2019), skin (Fundyler et al., 2004), larynx (Liu et al., 2005) cancer. The gene discussed is MMP2; the disease is carcinoma of esophagus.