Regarding in vivo studies, the pretreatment with carvacrol in colon cancer (Sivaranjani et al., 2016) and hepatocellular carcinoma (Jayakumar et al., 2012) increased the levels of enzymatic antioxidants such as GPx, SOD, CAT, GR, and GSH, revealing a chemopreventive effect of carvacrol and prevention of cell proliferation (Jayakumar et al., 2012; Sivaranjani et al., 2016). Here, SOD1 is linked to colonic neoplasm.