MAPK3 and malignant colon neoplasm: In addition, the level of phosphorylated ERK decreased in hepatocarcinoma, colon cancer, choriocarcinoma and prostate cancer cells, after treatment with carvacrol, and p-ERK1/2 levels decreased after thymol treatment in glioma cells (Yin et al., 2012; Fan et al., 2015; Heidarian and Keloushadi, 2019; Lim et al., 2019).