Although we have provided important evidence that STX1B gene is involved in the development of epilepsy and drug-resistant epilepsy at the genetic and expressional levels in Han Chinese, some limitations of this study should also be noted: First, our study only included the Han population, and the sample size was relatively small (We estimated that our study had 80% power to detect significant SNPs of MAF = 0.034 with relative risk >1.75). The gene discussed is STX1B; the disease is epilepsy.