In Stage II, we further explored the relationships between STX1B SNPs and drug-resistant epilepsy among 450 Han Chinese individuals (131 drug-resistant epilepsy patients, and 319 drug-responsive epilepsy patients), and again found this association remained after adjusting for age and gender and Bonferroni correction (OR = 0.260, 95%CI = 0.103–0.653, p = 0.004) in the dominant model (GT + TT vs. GG) (Table 5). The gene discussed is STX1B; the disease is epilepsy.