Caspase-9 interacts with necrosis mediator RIPK3 (receptor-interacting serine/threonine-protein kinase 3), and in an in vivo model of pancreatic necroptosis, knockout of caspase-9 from pancreatic acinar cells results in decreased severity of cerulein-induced acute pancreatitis (Molnár et al., 2021). This evidence concerns the gene RIPK3 and acute pancreatitis.