Most recently, Neidhardt et al. (Neidhardt et al., 2019) reported a 2-fold increase of D315 cl-caspase-9 in myocardial biopsies from patients with DCM and did not detect increased cl-caspase-3 or cl-caspase-8 expression. This evidence concerns the gene CASP3 and familial dilated cardiomyopathy.