XIAP overexpression confers neuroprotection in rodent and feline injury models (Zadro-Lamoureux et al., 2009; Wassmer et al., 2017), and pharmacological inhibition of caspase-9 by Pen1-XBir3 reduces severity of retinal detachment in mouse retinal vein occlusion (Avrutsky et al., 2020), supporting caspase-9 activity as a potential therapeutic target for retinal detachments. This evidence concerns the gene XIAP and retinal detachment.