CASP9 and early-onset autosomal dominant Alzheimer disease: Rohn et al. (Rohn et al., 2002) reported autocleaved (D315) caspase-9 expression in neurons and neurofibrillary tangles in hippocampal sections from patients with Alzheimer’s disease (AD), implicating caspase-9 activation and caspase-3 mediated cleavage of tau in AD pathogenesis.