Third, the activated CBP that owns activated histone acetyltransferase (HAT) activity acetylates H3 at Lys14, contributing to chromatin modification such as dissociating DNA and histone octamer, so that a variety of transcription factors such as NF-κB can specifically combine with DNA binding sites and activate gene transcription, thereby promoting the expression of pro-inflammatory molecules such as TSLP in patients with COPD (Chung et al., 2010; Anzalone et al., 2018) (Figure 4). Here, TSLP is linked to chronic obstructive pulmonary disease.