APOE and atherosclerosis: It is well-known that ApoE−/− mice is used to reduplicate the atherosclerosis model, and the vascular endothelial cell injury model is mostly HUVECs induced by ox-LDL or H2O2 (Li et al., 2004; Getz and Reardon, 2016; Pankratz et al., 2018; Huang et al., 2019).