APOE and ganglioneuroma: ELISA results showed that HFD could induce increases in serum IL-6, TNF-α, IL-8 and IL-15 of ApoE−/− mice, while GP, NR, and GN combination treatment could reduce the concentration of IL-6, TNF-α, IL-8 and IL-15, especially the GN combination (Figures 2A–D).