At the same time, HFD could significantly promote the protein expression of NLRP3, caspase-1, IL-1β, IL-18, ICAM-1, and VCAM-1 in the aortic tissue of ApoE−/− mice; these effects were significantly alleviated by GN combination (Figures 2E,F). The gene discussed is APOE; the disease is ganglioneuroma.