In this sense, the reduction in the cardiac ICa-L density correlated with a decreased expression of its channel-forming protein Cav1.2 in Akita mice, a genetic model of T1D with defective insulin production, as well as in models of T2D like the db/db obese mice and Zucker obese rats (Pereira et al., 2006; Lu et al., 2007; Fu et al., 2019). Here, INS is linked to type 1 diabetes mellitus.