RPS6KB1 and urinary bladder carcinoma: As shown in Figure 4A, PPM-18 elevated the phosphorylation of AMPK, whereas it decreased the phosphorylated levels of mTORC1 and P70S6K (a downstream of mTORC1) in T24 and EJ cells, indicating that PPM-18 could activate AMPK and conversely inhibit the mTORC1 pathway in bladder cancer cells.