The activation of histone acetylase by coactivators plays an important role in the regulation of different physiological responses, for example, PGC-1a plays a role in the activation of hyperglycemia, insulin resistance, and cardiomyopathy-related complexes, and transcriptional regulation of mRNA, CBP and SRC mainly regulate glucose and lipid metabolism. The gene discussed is PPARGC1A; the disease is cardiomyopathy.