TZDs, including rosiglitazone and pioglitazone, are synthetic full agonists of peroxisome proliferators activated receptor γ (PPARγ), and can activate PPARγ to better combine with insulin receptors for maintaining glucose levels and increasing adiponectin expression in patients with diabetes (Yki-Järvinen, 2004; Rizos et al., 2016). This evidence concerns the gene PPARG and diabetes mellitus.