HMGA1 and obesity due to melanocortin 4 receptor deficiency: However, administration of atorvastatin and AO (HFSS + atorvastatin and HFSS + AO 250 mg/kg, HFSS + AO 500 mg/kg) significantly increased the gene expression of PPAR-alpha (0.72 ± 0.02 folds, 0.57 ± 0.02 folds, and 0.66 ± 0.01 folds, respectively) and CYP7A1 (0.72 ± 0.05 folds, 0.43 ± 0.03 folds, and 0.84 ± 0.06 folds, respectively) while decreased the mRNA expression of HMGR (1.73 ± 0.31 folds, 5.41 ± 0.14 folds, and 2.93 ± 0.14 folds, respectively) when compared to obesity-induced hypertensive rats (HFSS group) (p < 0.001, Figure 5).