Our data showed that triclabendazole could induce apoptosis and secondary necrosis/pyroptosis by caspase-3 activation at least partly through augmenting the ROS/JNK/Bax-mitochondrial apoptotic pathway, and it also reduced the tumor volume in breast cancer cells by inducing apoptosis-to-pyroptosis. The gene discussed is MAPK8; the disease is breast cancer.