Interestingly, in this study, we found that triclabendazole significantly induces apoptosis in breast cancer cells typically swollen with evident large bubbles, including positive for annexin V staining, irregulation of Bax and Bcl-2, activation of caspase-3/7/8/9, and cleavage of PARP. The gene discussed is ANXA5; the disease is breast carcinoma.