ESR1 and osteoporosis: Phytoestrogens selectively bind to estrogen receptors, ERα and ERβ, like estrogens and are known to be effective in treating menopausal symptoms, such as osteoporosis, hot flashes and vasomotor symptoms, and anxiety and depression symptoms (Sirotkin and Harrath, 2014; Rodríguez-Landa et al., 2018).