SNCA and Parkinson disease: Somewhat pale staining structures with an ill-defined outline, immuno-reactive to α-synuclein, which are presumably the early stages of LBs, are also seen within neurons in substantia nigra as well as other parts of the PD brain including cortex and amygdala (Braak et al., 2004; Hartmann, 2004; Dickson, 2012; Kouli et al., 2018).