SNCA and Parkinson disease: Another important study corroborated the earlier findings of decreased α-synuclein and elevated levels of o-α-syn and pS129 in CSF in PD than that in controls, and further demonstrated that the combined measurements of o-α-syn/total α-synuclein and pS129/total α-synuclein could clearly improve the discrimination of PD from controls (Majbour et al., 2016).