Conversely, CYP46A1 inhibition could be of therapeutic value in pathological conditions that promote excessive glutamatergic excitation such as those occurring in schizophrenia, epilepsy, and hyperalgesia (Coyle, 2006; Xia et al., 2010; Sun et al., 2016b; Lu et al., 2020). This evidence concerns the gene CYP46A1 and epilepsy.