Hippocampal injection of the AAV-shRNA Cyp46a1 to wild type mice led to cognitive deficits, hippocampal atrophy, enhanced amyloid β (Aβ) production, abnormal tau phosphorylation, and stress of the ER, all symptoms strongly resembling AD phenotype (Djelti et al., 2015). This evidence concerns the gene MAPT and Alzheimer disease.