Finally, a list of pressing questions will be offered from the viewpoints of a biochemist (IAP), who pioneered the investigation of CYP46A1 pharmacological modulations and is now identifying brain processes affected by CYP46A1 activity, and a gene therapy neuroscientist (NC), aiming to ultimately bring this therapeutic target to patients affected with severe neurodegenerative diseases. Here, CYP46A1 is linked to neurodegenerative disease.