MAPT and Alzheimer disease: Aβ and tau proteins are the two most concerning neurotoxic waste proteins due to their accumulation in the brain and association with neurological diseases such as AD and TBI (Berrouschot et al., 1998; Arbel-Ornath et al., 2013; Hinson et al., 2013; Tsitsopoulos and Marklund, 2013; Iliff et al., 2014; Kyrtsos and Baras, 2015; Plog et al., 2015; Tarasoff-Conway et al., 2015; Louveau et al., 2016; Peng et al., 2016; Xia et al., 2017; Da Mesquita et al., 2018b; Goodman et al., 2018; Reeves et al., 2020).