Zambrano et al. (2008) showed that infection of primary neurons with HSV-1 caused significant neuronal damage and death via hyperphosphorylation of Tau, increased acetylation and tyrosination of tubulin, disrupted microtubules, and damaged and shortened neurites. Similarly, HSV-1 induced GSK3-β and protein kinase A-mediated Tau hyperphosphorylation (Wozniak et al., 2009a). Here, MAPT is linked to infection.