• Found HSV-1 antibodies in female AD patients over 60 years of age (Lövheim et al., 2015a) • Detected HSV-1 DNA in the brains of AD patients (Wozniak et al., 2009b) • Increased β-amyloidosis as an antimicrobial defense mechanism, which increased senile plaque formation (Eimer et al., 2018) • Promoted Tau hyperphosphorylation and damage in primary neurons (Zambrano et al., 2008). The gene discussed is MAPT; the disease is Alzheimer disease.