Notably, mutant PD-causative forms of LRRK2 induce dystrophic neurites and can also decrease the number of neurites (MacLeod et al., 2006; Li et al., 2009), indicating that it would be beneficial for dopamine neurons to counteract such processes by modulating the transcriptome accordingly to promote neurite extension. This evidence concerns the gene LRRK2 and Parkinson disease.