SYP and Alzheimer disease: Loss of SYP staining is observed in neurons in the vicinity of Aβ oligomer deposits (Ishibashi et al., 2006); interaction of SYP with internalized Aβ and Aβ-induced preferential SYP nitration have been suggested to mediate synaptic disturbances observed in AD (Tran et al., 2003; Russell et al., 2012).