VAMP2 and Alzheimer disease: Several lines of evidence suggest the possible engagement of SNARE proteins in AD, although data are rather limited: polymorphisms in VAMP1 and STX genes associate with AD; VAMP1 can modulate Aβ secretion; while VAMP2 levels are disturbed in AD (Sevlever et al., 2015; Vallortigara et al., 2016; Costa et al., 2019).