In this cohort of CV patients, no significant associations between SNPs in CD14 (rs2569190), NF-κΒ (rs28362491), TLR2 (rs5743708), and TLR4 (rs4986790) and the prevalence of severe periodontitis was proven considering codominant, dominant, and recessive genetic models as well as allele distribution. Here, TLR2 is linked to periodontitis.