And indeed, in a variety of case-control studies as well as in meta-analyses, their impact on periodontitis as well as CV diseases was assessed (CD14 [15–17], NF-κΒ [14, 18, 19], TLR2 [20, 21], and TLR4 [4, 22, 23]). This evidence concerns the gene TLR4 and periodontitis.