Based on the data available, we assessed in our study the impact of SNPs in TLR2 (rs5743708), TLR4 (rs4986790), CD14 (rs2569190), and NF-κΒ (rs28362491), on severe periodontitis as well as on the incidence of new CV events within a three year follow-up in a cohort of CV patients. Here, TLR4 is linked to periodontitis.