In this cohort of CV patients, no significant associations between SNPs in CD14 (rs2569190), NF-κΒ (rs28362491), TLR2 (rs5743708), and TLR4 (rs4986790) and the prevalence of severe periodontitis was proven considering codominant, dominant, and recessive genetic models as well as allele distribution. The gene discussed is CD14; the disease is periodontitis.