Earlier studies have provided strong evidence that activated myeloid cells play a major role in the exacerbation of exudative AMD, e.g., myeloid cells in the CNV lesions express VEGF-A in patients with exudative AMD, and pharmacological inhibition of myeloid cell infiltration into the subretinal space significantly reduced the area of the CNV in the laser-induced CNV model [19, 34–36]. This evidence concerns the gene VEGFA and age-related macular degeneration.