For head and neck squamous cell carcinoma (HNSCC), a higher NR2F6 protein level had been detected in primary tumors that developed into locally recurrent tumors compared with nonrecurrent primary cancers, indicating high expression of NR2F6 protein may be a useful biomarker for early prediction of local recurrences in HNSCC [19]. The gene discussed is NR2F6; the disease is head and neck squamous cell carcinoma.