Feng et al. analyzed the expression of CASR, COL4A1, GPR4, MMP2, DCN, UTS2, and LDLR genes, which may be applied to improve RCC diagnosis and considered potential treatment targets, using information from Gene Expression Omnibus database with the help of Gene Set Enrichment Analysis, Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, and Protein–protein Interaction method [32]. This evidence concerns the gene GPR4 and renal cell carcinoma.