NEP also hydrolyzes both Ang I and Ang II.14–16 Initially, it was hypothesized that inhibition of the natriuretic peptide system would counter-regulate the detrimental effects of renin-angiotensin-aldosterone system upregulation in hypertension by increasing accumulation of the vasodilators BK and natriuretic peptides. The gene discussed is AGT; the disease is hypertensive disorder.