In the Ecuadorian cohort, not a single case of cancer was noted during a 22 years follow-up, while in cohorts of GHD patients due to GHRH-R defect or congenital isolated or multiple GHD, in which small amounts of circulating GH can be demonstrated, few cases of cancer have been reported both in naïve and in patients treated with GH [67]. This evidence concerns the gene GHRHR and cancer.