In an effort to understand the functional basis of the intrinsic chemoresistance associated with increased MYC and BCL-2 levels in a significant fraction of DLBCL, we hypothesized that: 1) Overexpression of DDR and oxidative DNA damage markers (γH2AX and 8-OHdG) could identify poor prognosis DLBCL subsets. Here, BCL2 is linked to diffuse large B-cell lymphoma.