Since chemotherapy exerts its cytotoxic effects through exogenous DNA damage and induction of reactive oxygen species (ROS), adaptive mechanisms to replicative and oxidative stress (consisting in DDR activation and upregulation of antioxidant capacity), could represent the biologic basis of the poor prognosis and chemoresistance observed in MYC/BCL-2-double expresser DLBCL and HG-BCL w/DH. Here, MYC is linked to diffuse large B-cell lymphoma.