The majority of infant ALL patients carry one of three recurrent types of MLL translocations in which the MLL gene becomes fused to either AF4 (aka AFF1; 49% of the cases), ENL (aka MLLT1; 22% of the cases), or AF9 (aka MLLT3; 16% of the cases) [1]. This evidence concerns the gene MLLT3 and acute lymphoblastic leukemia.