ALDH7A1 and neoplasm: Recently, Longo et al. also found that phosphodiesterase (PDE) inhibitors can enhance statin-induced apoptosis, which may pave the way for the combination of PDE inhibitors and statins in the treatment of hematological malignancies [307].Therefore, a large body of preclinical and clinical evidence shows that statins play a synergistic anti-tumor role when administered in combination with conventional cancer therapy.