In addition, our findings also showed that HOXB7 as a putative oncogenic mediator underlying HNSCC initiation and progression, which suggested that selective targeting of HOXB7 by genetic or chemical approach might hold translational promise against but to further explore this, more work on finding out the exact HOXB7 regulatory network need be down in the future as well as novel inhibitors targeting HOXB7. This evidence concerns the gene HOXB7 and head and neck squamous cell carcinoma.