Obesity is a chronic low-grade inflammatory disease where the adipocytes secrete dozens of biologically active molecules such as leptin, resistin, tumor necrosis factor α (TNF-α), interleukins:IL-1, IL-6, IL-8 and IL-10, growth factors, complement components, angiotensinogen, plasma plasminogen, activator-1(PAI-1), and a number of other substances. Here, TNF is linked to obesity due to melanocortin 4 receptor deficiency.