HOXC10 and cancer: We have shown that HMS depletion leads to suppression of the cancer-related phenotypes, and thus, next we wanted to establish if this observed suppression is due to the downregulation of HOXC10. We transfected HOXC10-4HA expressing stable cells with HMS siRNA, which only depletes the endogenous HOXC10 protein without affecting the exogenous HOXC10-4HA, and these cells were then evaluated for their colony forming ability.