For example, lncRNA MYU functions downstream of Wnt/c-Myc signaling to promote tumorigenicity of colon cancer cells, lncRNA ZFAS1 promotes metastasis of clear cell renal cell carcinoma by targeting the miR-10a/SKA1 pathway, lncRNA EMSLR induces tumorigenesis via the c-Myc pathway, and lncRNA PCAT6 induces cell growth and metastasis via Wnt/β-catenin pathway (14, 34, 35, 36). The gene discussed is VPS9D1-AS1; the disease is clear cell renal carcinoma.