Indeed, in an oncogene-induced model of prostate cancer in mice, attenuation of TGF-β signalling in T cells resulting from expression of the Cd4-Tgfbr2dn transgene was associated with increased infiltration of tumors by CD4 and CD8 T cells expressing high levels of IFNγ and Gzmb [50]. This evidence concerns the gene CD4 and prostate cancer.