IL10 and experimental autoimmune encephalomyelitis: In addition to IL-10, Breg-derived transforming growth factor β1 (TGF-β1) and interleukin 35 (IL-35) also have been demonstrated to mediate the protective roles of Bregs against dextran sodium sulfate-colitis, experimental autoimmune encephalomyelitis, and experimental uveitis [39, 42, 47].