However, transfer of Bregs in the presence of anti-TGF-β1 and anti-EBI3 antibodies still had protective effects on MI, with comparable cardiac function, scar size and fibrosis compared to the effects of the transfer of Bregs with isotype control antibodies (Supplementary Figs. 8 and 9). The gene discussed is EBI3; the disease is myocardial infarction.