Different cytokines have been identified as suppressive cytokines produced by Bregs, and most studies have demonstrated a key role for B cell-derived IL-10, a hallmark cytokine of Bregs, in the suppression of different disease models, such as arthritis, experimental autoimmune encephalomyelitis and colitis [23, 32, 52]. Here, IL10 is linked to experimental autoimmune encephalomyelitis.