Recent studies identified features predictive of dismal outcome in MB patients: they include amplification or overexpression of the MYC oncogene, < 3 years of age, subtotal resection (STR defined as leaving > 1.5 cm2 of residual tumour), dissemination at diagnosis and large-cell/anaplastic histology (LCA) [67, 79]. Here, MYC is linked to neoplasm.