OTX2 and neoplasm: Since MB represents a very heterogeneous family of tumours requiring different therapeutic approaches to obtain reliable results, we decided to test the combination of both WP1066 and CQ in a MBGroup3 mouse model, in which tumours are induced by c-Myc and orthodenticle homeobox 2 (Otx2) overexpression in P0 CD1 mice cerebella, as previously described [10, 57].