PRNP and early-onset autosomal dominant Alzheimer disease: Several of these uniquely detected isoforms had high read support and came from genes such as AP2, APBB, HNRNPM, DCTN2, PRNP, MICU1, SEPTIN7 and APBB1, that have been studied in relation, or linked directly, to Alzheimer’s disease (Bagyinszky et al., 2019; Calvo-Rodriguez et al., 2020; Geuens et al., 2016; Tanahashi and Tabira, 1999; Tian et al., 2013; Wang et al., 2018) or other neurodegenerative disorders (Boland et al., 2018; Charbonnier et al., 1997).