ACE and dementia: One of them reported a two-fold higher risk of dementia in ACE II homozygotes compared to combined ID and DD genotypes (OR 2.17; 95% CI 1.22–3.85; p = 0.008); moreover, II carriers were more likely to develop dementia under the age of 70 (OR 4.35; 95% CI 1.37–13.86; p = 0.013) [28].