Basal phosphorylation of IR and AKT in liver, which is driven primarily by circulating insulin levels, was upregulated in HF diet-fed WT mice but not IL-4Rα-deficient mice (Fig. 1K), despite increased basal AKT phosphorylation in IL-4Rα-deficient mice fed chow diet. This evidence concerns the gene AKT1 and hydrops fetalis.