RB1 and hepatocellular carcinoma: In comparison, the most common chromosomal aberrations reported in HCC are the gains of 1q (suggested target genes include WNT14, FASL) and 8q (MYC, WISP1) and the loss of 17p (TP53, HIC1), followed by losses of 4q (LEF1, CCNA) and 13q (RB1, BRCA3) [42, 43] (Fig. 3E).