LPAR1 and cancer: LPAR3 reportedly contribute to tumor invasion and malignancy in some types of cancers [30], and the G proteins responsible for downstream signaling of LPAR3 are Gαi/o and Gαq/11, which partially overlap with those of LPAR1, Gα12/13, Gαi/o, and Gαq/11 [35, 36].