LPAR1 and cancer: Similar to the results from LPAR1 KO cells, the amount of cancer cells trapped in the lung was not significantly modified by the drug treatment on the day of cell injection; however, the pre-administration of ONO-7300243 significantly suppressed the engraftment of HuO9/Akaluc cells in the lung (Fig. 6B, C), which confirmed that treatment with ONO-7300243 for 72 h was not cytotoxic to the HuO9 cells in vitro (Supplementary Fig. S7).