In addition to the association of THEMIS with celiac disease, two loci with rare variants have been reported of association with autoimmune diseases, i.e., the long intergenic non-protein coding RNA 1967 (LINC01967) and C-X9-C motif containing 1 (CMC1) locus at chr3p24.1 has been reported to be associated with multiple sclerosis36, and the small nucleolar RNA, C/D box 3F (SNORD3F)/leucine zipper tumor suppressor 1 (LZTS1) antisense RNA 1 (LZTS1-AS1) locus at chr8p21.3 which has been reported to be associated with rheumatoid arthritis37. Here, PTGDR is linked to autoimmune disease.