Additionally, the cohort analysis identified pairs with significant co-occurrence, including KRAS and APC, TP53 and APC, KRAS and CDKN2A, KRAS and STK11, KRAS, KEAP1, and SMARCA4 and KEAP1, highlighting the importance of these oncogenes in CUP tumours. Here, KEAP1 is linked to neoplasm.