Among the six significant associations found by PheRS with pre-selected phecodes, three significant associations in the European ancestry, CFTR and CAD, CFTR and HF, and LDLR and HF, are replicated in the African American population with nominal significance (p = 3.53E−02, p = 1.95E−02, and p = 4,81E−02, respectively). Here, CFTR is linked to hydrops fetalis.