TRAF6 and chronic kidney disease: In this study, we showed that anakinra attenuated inguinal WAT protein and mRNA content of Cox2 and Pgf2α level in CKD mice as well as normalized key inflammatory molecules (Tlr2, MyD88 and Traf6) involved in adipose tissue browning in CKD mice (Fig. 5 and Supplemental Fig. 1).