Anakinra treatment normalized (Atf3, Atp2a2, Fhl1, Fosl2, Gng2, Itp1, Lamc3, Mafb, Maff, Myl2, Nlcr3, Pth1r, Tnnc1, Tpm3, Ucp2) and attenuated (Csrp3, Cyfip2) gene expression in muscle from CKD mice (Fig. 8). The gene discussed is LAMC3; the disease is chronic kidney disease.