Several previously reported protective genes (hypoxia inducible factor 1, HIF-1α; heme oxygenase 1; HO-1, colony-stimulating factor 2, CSF-2; bone morphogenetic protein-7, BMP-7; and activin-like kinase 3; ALK3) against renal fibrosis progression after ischemia reperfusion were evaluated after IR. Here, HMOX1 is linked to renal fibrosis.