However, when the factors are combined (i.e. age, prostate volume, and FLNA levels) this yielded a diagnostic performance that is improved over that of PSA alone in discriminating patients with LUTS/BPH from PCa in patients who have had multiple biopsies (AUC 0.87 vs. 0.52; Fig. 3B; Table 2). The gene discussed is KLK3; the disease is posterior cortical atrophy.