All these cytokines (IL-1β, TNFα, IL5, IL-11, IL-15, IL-24, IL-26, IL-32) that contribute to the RA pathophysiology were increased in the RA PBMCs dataset with significantly high ADA expression compared to synovial macrophages with insignificant ADA expression compared to control. This evidence concerns the gene IL15 and rheumatoid arthritis.