Furthermore, integration of protein association- and transcription factor-derived networks delineated putative Pkd-dependent regulatory cascades in mIMCD3 cells: 5 ABC25 genes (Cd34, Spp1, Cdh2, C3 and Mmp2) were linked to 6 of the TF7 transcription factors, thus, further connecting phenotypic ADPKD pathogenesis to the unknown cellular functions of PKD1 and PKD2 (Fig. 4e). This evidence concerns the gene SPP1 and autosomal dominant polycystic kidney disease.