PKD1 and autosomal dominant polycystic kidney disease: To expand our mechanistic understanding of New61 in PC-1/TRPP2 signaling and identify novel targets for development in ADPKD, we probed the pathophysiological relevance of respective genes by applied bayesian inference48: (1) Through identification, New61 genes were selected to show significant concordant changes (log2 fold change ≥|1|) in Pkd1- and Pkd2-deficient mIMCD3 cells (Fig. 6c).