C3 and autosomal dominant polycystic kidney disease: Furthermore, integration of protein association- and transcription factor-derived networks delineated putative Pkd-dependent regulatory cascades in mIMCD3 cells: 5 ABC25 genes (Cd34, Spp1, Cdh2, C3 and Mmp2) were linked to 6 of the TF7 transcription factors, thus, further connecting phenotypic ADPKD pathogenesis to the unknown cellular functions of PKD1 and PKD2 (Fig. 4e).