APLN and autosomal dominant polycystic kidney disease: Of those, 31 replicated in ≥ 3 independent transcriptional profiles (Rep31), with six genes (ALDH2, APLN, GAL3ST1, HS6ST2, PANK1 and PCSK9) showing concordant regulation across studies, substantiating their pathophysiological relevance in ADPKD (Figs. 6a,b, S6b,c).