We further validated the effects of compound treatment (RECTAS, TG003, INDY, CaNDY, ALGERNON, and SRPIN340) and knockdown of SRSF6 or CLK in FD patient fibroblasts with the homozygous IKBKAP-FD IVS20 + 6 T > C mutation, and confirmed the increased IKBKAP-FD exon 20 skipping by CLK inhibition (Fig. 2g and Supplementary Fig. 1a) or depletion for SRSF6 or CLK (Fig. 2h and Supplementary Fig. 2a) for the endogenous transcripts. This evidence concerns the gene CLK1 and Fabry disease.